The first thing to do is to join an affiliate program then select the products you intend to sell. The owners of the products would provide you with an affiliate code you can use for referring traffic to the main site. Also, you will be offered banners, text links and several forms of creative copies in which you just copy and paste the code on your own site to refer traffic.
There are also a lot of customization options. You can integrate hotel booking sites into your website, choose specific destinations, and showcase properties that interest you. For example, you could start a niche affiliate site about “Denver Family Vacations,” write content about the top things to do in Denver, guides about the local area, and promote specific hotels.